Yes, you can configure the GPUs options in the plugin options panel, GPUs tab. In this tab, you can not only enable the GPUs that will be used for rendering, but also their priority and GPUs are enabled for tonemaping and for denoising. https://docs.otoy.com/HoudiniH/HoudiniP ... ptions.htm
From any script or from the non-GUI tools like hython, you can also configure the GPUs using the "Octane_setGPU" HScript command.
Computer Graphics Software Developer Octane plugin development and support: LightWave and Houdini