It seems according mobos and cpus need to be chosen with care (#slots, #lanes, price, ...).
There are quite some threads about high-end workstation building around here.
The question is, if no high-end cpu is needed (just basic 3d modelling, rendering on gpu), would not vintage hardware be enough, namely:
- ASUS RAMPAGE IV FORMULA
- i7-3930k (40 lanes)
to support quad GTX/RTX...
I found one thread from 2012

The recommendations seem to tend towards high end mobos, but I have not yet understood why...if all magic happens on GPU...
Thanks