We got a new workstation in the office for rendering stuff (what else

We tried to render different scenes and got some problems, crashes, freezes, etc. using it as a slave didn't show any problems or I just didn't recognize them.
For animations we got problems rendering over night, or after like 3-5 hours.
before I do a big documentation of what we tried and what problems we got, there are maybe some of you have a simular setup without problems.
Threadripper 2950x
Gigabyte X399 Designare
128 GB RAM
4x 2080 ti
Win 10
C4D R20
Octane V4 (tried 4.02.1-R3, 4.03, 4.04)
Driver (tried 417.22, 417.71, 419.17)
Anyone who have simular or maybe same CPU+Mainboard+GPU setup?
Using only 3 cards works fine. Deactivating one of them (not one specific card).
And what about single Octane Bench results: Is it normal to have one card that has lower OB? I got 307, 309, 311 and 244. Testing all separate (OB 4.00c).
I'm at the end of my little knowledge.