In the octane Settings Panel | Devices there is nothing listed.
If I try to render I get:
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Started logging on 04.03.16 23:43:44
OctaneRender 2.25 (2250000)
CUDA error 999 on device -1: An unknown internal error occurred.
-> failed to initialise CUDA driver API
CUDA error 999 on device -1: An unknown internal error occurred.
-> failed to initialise CUDA driver API
Scene created in plugin version -1
There is no CUDA device which is supported by Octane Render...
Tried to access null node
Tried to access pin via an invalid ID P_MESH (111)
Tried to access null node pin
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Since I was having problems, I installed the latest nVidia drivers (362.00) but that didn't help.
This is in Windows 10 64 bit, C4D 15
I am able to render with stand-alone Octane, and it sees the cuda device fine.

Any idea what would cause this?