please note that C4D R21 works perfectly under both Catalina and Big Sur, you can have issues with R20 (not fully 64bit), but R21 should work as expected
About AMD Radeon 580, it is a Polaris GPU, so only supported by latest Apple Metal driver in Mac Os 11.x Big Sur.
Catalina has a limited number of supported AMD GPUs, while Mojave does not support GPU rendering in any way, no Metal, no CUDA rendering on 10.14.x.
So, Big Sur 11.x is the best choice, Apple has stopped to develop the metal driver for Catalina, and in 11.4 is going to arrive the support for new AMD Big Navi 6X00 GPUs.
Happy Mac GPU rendering,
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