i've noticed that if i do a region render and the render completes (in my case with denoising), when i try to restart the render by pressing play again, changing something etc, Octane is unresponsive and laggy and when the render does get going again it's way slower than before (10x slower or worse)
i have to stop/start/reload the render to respond again but this wastes a lot of time as it takes a while for the scene to reload
if i make changes before the render completes (even if doing a region render) everything works as normal
of course i need to complete the render to get the denoised image
hope that makes sense