Have you done the LiveDB tutorial
http://www.youtube.com/watch?v=d5Q1EFXIu_I Individual Materials in LiveDB can have a plethora of settings.
The examples below show a SKP with a plain 'pink' material and a textured brick material with two UV-mappings [the right one is 0.5 scaled] - in SKP and in OCS.
You can see that using the LiveDB>Material>Skin>Leather gives the same appearance to both swapped [relinked] materials, with both brick faces looking the same even with their different UV-mapping in the SKp and original OCS view.
However, using the LiveDB>Material>Cloth>Wallpaper gives different appearances to ALL materials, the originally untextured 'pink' seems to loose all scaling, and the two brick textured faces now seem to respect the different UV-mapping this time - as one might expect.
It
is possible to Edit the settings for the LiveDB materials so the size changes...
As far as I can see you need to plan your SKP with the use of LiveDB in mind - swapping out only one SKP material for one LiveDB material; adjusting the LiveDB's texture scaling to suit, especially if the SKP material UV-mapping has been adjusted or the material is 'plain' [untextured]. You need to plan the size of a SKM texture so that you don't UV-map scale it in the SKP, as this will affect the LiveDB material scaling. There seems to be considerable differences between LiveDB materials' initial settings, so you must adjust each swapped material to suit your needs - it is unlikely to work straight out the box every time...