My scene was working ok until I added an additional View Layer. A total of 3 view layers or more and I get the "No Server at 220.127.116.11" for what ever that means. Got rid of the view layers and things are working again.
A. MacOS BigSur 11.2.3
B. AMD Radeon Pro Vega II Duo 32 GB
C. 384 GB 2933 MHz DDR4
G. Octane PR8 Blender