Regarding eGPUs, my experience is anything beyond two puts you in the realm of a lot of extra cost for not a lot of extra performance, for reasons alluded to earlier (controller limitations). If using a 15 or 16" MBP (say 2017 or later), plug one eGPU into each side of the Mac after you've booted it, and make sure the other two TB3 ports are unused. For other Macs, the TB3 controller mix is here:
mini:
https://support.apple.com/en-us/HT209224iMac Pro:
https://support.apple.com/en-us/HT208366Mac Pro:
https://support.apple.com/en-us/HT210228From there probably the simplest setup is to connect one of the eGPUs to your main external display, make sure in the Display prefs that that display is the main one and then launch away / start experimenting. You should be able to select both GPUs in Octane as in other apps, even though only one is driving a screen. Example: you can do this with DaVinci Resolve. Still a noob with Octane but if it supports multiple GPUs as folks are saying, shouldn't be an issue.
PS - to answer the earlier questions the Radeon VII, it is about the best you can do right now on a Mac (barring the top-end cards in 2019 Mac Pro). If you can't find one of those and don't want to spend a lot on their blue workstation cards (most of which are either old or new and lower-tier), the 5700 XT is currently a solid all-around card with performance that is close to the Radeon VII in most categories. When the Radeon
PRO VII ships it will probably kick the pants off everything for a short time (and kick your wallet in the pants). Until the RDNA 2 (aka "Big Navi") cards ship, which will bring significant improvements including hardware ray-tracing (AMD's answer to RTX) as I understand it. Those cards are to be announced "any day now" but with Covid everything is uncertain (more than usual). Another thing to keep in mind: any new card is pretty much useless to you until Apple ships a driver for it, which always come with future OS versions.
So if you can get a 5700 XT (or x2) now you might be able to get some good mileage out of that since RDNA2 cards: a) likely won't ship for 2-3 months, and b) Apple might not have a driver until 2-3 months after that with all the other stuff they're working on.